Picks · Oct 21, 2026
San Francisco 49ers
NFC West
6-0Record
4-2ATS
3-3O/U
Next game
NFC West
- 149ersSF6-0—
- 2
SeahawksSEA3-33 - 3
CardinalsARI2-44 - 4
RamsLAR2-44
Game odds
The best available line on each side of the next game.
Recent games
2026 betting trends
How the San Francisco 49ers performed straight up, against the spread and on the total — at home, on the road, and in division play.
ATS4-267% cover rate
O/U3-350% over rate
| Split | W-L | ATS | O/U |
|---|---|---|---|
| Overall | 6-0 | 4-2 | 3-3 |
| Home | 4-0 | 2-2 | 2-2 |
| Away | 2-0 | 2-0 | 1-1 |
| Division | 3-0 | 2-1 | 2-1 |
| Conference | 4-0 | 2-2 | 2-2 |
Smart money
Futures
Season-long odds and how they’ve moved.
Championship
Super Bowl Winner+550Open +1800
Conference+225Open +1000
Division Winner-612Open +250
Season outcomes
Make Playoffs
Yes-5000Open -160
No+1500Open +125
Season Wins 13.5
Over+110Open +126
Under-140Open -150
Latest news
San Francisco 49ers coverage, plus the league-wide picks they appear in.