49ers are Week 1's biggest road favorites against the Lions; O/U 45.5
Thu, Sep 2nd 5:15pm EDT
San Francisco's -7.5 point spread makes them the biggest road favorites of the Week 1 slate. Both teams will look different at quarterback this year. The 49ers may use rookie Trey Lance in some packages early to spell Jimmy Garoppolo, while the Lions have Jared Goff under center after dealing Matthew Stafford to the Rams. This game also marks the Lions debut for head coach Dan Campbell. The 49ers went 7-9 ATS last year, and had an over/under record of 8-8. The Lions went 5-10-1 ATS last year and had an over/under record of 9-6-1.